Publications

publications by categories in reversed chronological order. generated by jekyll-scholar.

2025

  1. PNAS
    Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery
    Yue Xu, Fanglin Gong, Alex Golubovic, Amy Strilchuk, Jingan Chen, Muye Zhou, Songtao Dong, Breanna Seto, and Bowen Li
    Proceedings of the National Academy of Sciences, 2025
    Website
  2. bioRxiv
    LUMI-lab: a Foundation Model-Driven Autonomous Platform Enabling Discovery of New Ionizable Lipid Designs for mRNA Delivery
    Haotian Cui, Yue Xu, Kuan Pang, Gen Li, Fanglin Gong, Bo Wang, and Bowen Li
    bioRxiv, 2025
    Website
  3. Small
    Deep Red-Light-Mediated Nitric Oxide and Photodynamic Synergistic Antibacterial Therapy for the Treatment of Drug-Resistant Bacterial Infections
    Jingjing Lin, Mingyi Cao, Shiya Wang, Xinyu Wu, Yuhan Pan, Zhiyue Dai, Ningge Xu, Lumin Zuo, Ji Liu, Yuxin Wang, and  others
    Small, 2025
    Website
  4. Bioorg Chem
    Photoresponsive nitric oxide photocage/photodynamic integrated prodrug for advanced management of drug-resistant bacteria-infected wound therapy
    Jingjing Lin, Shiya Wang, Mingyi Cao, Yuhan Pan, Zhiyue Dai, Yuxin Wang, Zhiyuan Jin, Yue Xu, Jianbing Wu, Ji Liu, and  others
    Bioorganic Chemistry, 2025
    Website
  5. ACS Bio & Med Chem Au
    A Reverse Transcription Nucleic-Acid-Based Barcoding System for In Vivo Measurement of Lipid Nanoparticle mRNA Delivery
    Kevin C Wang, Tiana L Young, Jingan Chen, Shannon N Tsai, Yue Xu, Andrew J Varley, Nicholas C Solek, Fanglin Gong, Rick XZ Lu, Basil P Hubbard, and  others
    ACS Bio & Med Chem Au, 2025
    Website

2024

  1. Nat Commun
    AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery
    Yue Xu, Shihao Ma, Haotian Cui, Jingan Chen, Shufen Xu, Fanglin Gong, Alex Golubovic, Muye Zhou, Kevin Chang Wang, Andrew Varley, and  others
    Nature communications, 2024
    Website
  2. Adv Mater
    Tumor-tailored ionizable lipid nanoparticles facilitate IL-12 circular RNA delivery for enhanced lung cancer immunotherapy
    Shufen Xu, Yue Xu, Nicholas C Solek, Jingan Chen, Fanglin Gong, Andrew James Varley, Alex Golubovic, Anni Pan, Songtao Dong, Gang Zheng, and  others
    Advanced Materials, 2024
    Website

2023

  1. J Mater Chem B
    Rational design and combinatorial chemistry of ionizable lipids for RNA delivery
    Yue Xu, Alex Golubovic, Shufen Xu, Anni Pan, and Bowen Li
    Journal of Materials Chemistry B, 2023
    Website
  2. Nat Biomed Eng
    Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA
    Bowen Li, Allen Yujie Jiang, Idris Raji, Caroline Atyeo, Theresa M Raimondo, Akiva GR Gordon, Luke H Rhym, Tahoura Samad, Corina MacIsaac, Jacob Witten, and  others
    Nature Biomedical Engineering, 2023
    Website
  3. PNAS
    Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects
    Jingan Chen, Yue Xu, Muye Zhou, Shufen Xu, Andrew James Varley, Alex Golubovic, Rick Xing Ze Lu, Kevin Chang Wang, Mina Yeganeh, Daniel Vosoughi, and  others
    Proceedings of the National Academy of Sciences, 2023
    Website

2022

  1. Biomater Sci
    Recent advances in in situ oxygen-generating and oxygen-replenishing strategies for hypoxic-enhanced photodynamic therapy
    Shuheng Qin, Yue Xu, Hua Li, Haiyan Chen, and Zhenwei Yuan
    Biomaterials Science, 2022
    Website
  2. Acs Sensors
    β-Lactamase-responsive probe for efficient photodynamic therapy of drug-resistant bacterial infection
    Yue Xu, Haiyan Chen, Shufen Xu, Ji Liu, Yang Chen, Lijuan Gui, Hua Li, Ruixi Li, Zhenwei Yuan, and Bowen Li
    Acs Sensors, 2022
    Website
  3. Chem Eng J
    Monitoring inflammation-cancer progression by cell viscosity, polarity and leucine aminopeptidase using multicolor fluorescent probe
    Ruixi Li, Jingxuan Guo, Yishan Duan, Xian Liu, Lijuan Gui, Yue Xu, Xiangkai Kong, Yongjun Li, Haiyan Chen, and Zhenwei Yuan
    Chemical Engineering Journal, 2022
    Website
  4. Nanomedicine
    Potential of fluorescent nanoprobe in diagnosis and treatment of Alzheimer’s disease
    Jingjing Lin, Hanhan Li, Jingxuan Guo, Yue Xu, Hua Li, Jun Yan, Yuxin Wang, Haiyan Chen, and Zhenwei Yuan
    Nanomedicine, 2022
    Website

2021

  1. J Adv Res
    Development of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogs
    Yue Xu, Hua Li, Lixue Fan, Yisha Chen, Li Li, Xiaojing Zhou, Ruixi Li, Yuru Cheng, Haiyan Chen, and Zhenwei Yuan
    Journal of advanced research, 2021
    Website
  2. Anal Chim Acta
    A near-infrared fluorescent probe with large Stokes shift for visualizing and monitoring mitochondrial viscosity in live cells and inflammatory tissues
    Lixue Fan, Yanping Pan, Weiqing Li, Yue Xu, Yishan Duan, Ruixi Li, Yanqing Lv, Haiyan Chen, and Zhenwei Yuan
    Analytica Chimica Acta, 2021
    Website
  3. J Med Chem
    Light-triggered fluorescence self-reporting nitric oxide release from coumarin analogues for accelerating wound healing and synergistic antimicrobial applications
    Yue Xu, Hua Li, Shufen Xu, Xian Liu, Jingjing Lin, Haiyan Chen, and Zhenwei Yuan
    Journal of Medicinal Chemistry, 2021
    Website

2020

  1. Biomater Sci
    A visible and near-infrared dual-fluorescent probe for discrimination between Cys/Hcy and GSH and its application in bioimaging
    Ruixi Li, Habtamu Kassaye, Yanping Pan, Yuanzhi Shen, Weiqing Li, Yuru Cheng, Jingxuan Guo, Yue Xu, Hongping Yin, and Zhenwei Yuan
    Biomaterials Science, 2020
    Website
  2. Anal Chim Acta
    A family of push-pull bio-probes for tracking lipid droplets in living cells with the detection of heterogeneity and polarity
    Li Li, Yue Xu, Yisha Chen, Jinrong Zheng, Juanjuan Zhang, Ruixi Li, Hao Wan, Jun Yin, Zhenwei Yuan, and Haiyan Chen
    Analytica Chimica Acta, 2020
    Website
  3. Small
    A Bioresponsive Near-Infrared Fluorescent Probe for Facile and Persistent Live-Cell Tracking
    Jinrong Zheng, Yue Xu, Lixue Fan, Shuheng Qin, Hua Li, Mangmang Sang, Ruixi Li, Haiyan Chen, Zhenwei Yuan, and Bowen Li
    Small, 2020
    Website

2019

  1. Chem Mater
    Near-infrared-light-responsive lipid nanoparticles as an intelligent drug release system for cancer therapy
    Fei Wang, Zhenwei Yuan, Patrick McMullen, Ruixi Li, Jinrong Zheng, Yue Xu, Mingjun Xu, Qing He, Bowen Li, and Haiyan Chen
    Chemistry of Materials, 2019
    Website
  2. Sens Actuators B Chem
    The visualization of lysosomal and mitochondrial glutathione via near-infrared fluorophore and in vivo imaging application
    Zhiqiang Xu, Ming-Xing Zhang, Yue Xu, Sheng Hua Liu, Lintao Zeng, Haiyan Chen, and Jun Yin
    Sensors and Actuators B: Chemical, 2019
    Website
  3. Mol Pharm
    Application of Nitroimidazole–Carbobane-Modified Phenylalanine Derivatives as Dual-Target Boron Carriers in Boron Neutron Capture Therapy
    Ruixi Li, Juanjuan Zhang, Jingxuan Guo, Yue Xu, Kunyuan Duan, Jinrong Zheng, Hao Wan, Zhenwei Yuan, and Haiyan Chen
    Molecular pharmaceutics, 2019
    Website
  4. Talanta
    A visible and near-infrared, dual emission fluorescent probe based on thiol reactivity for selectively tracking mitochondrial glutathione in vitro
    Yue Xu, Ruixi Li, Xiaojing Zhou, Weiqing Li, Umeorah Ernest, Hao Wan, Li Li, Haiyan Chen, and Zhenwei Yuan
    Talanta, 2019
    Website

2018

  1. Biomater Sci
    Thermosensitive drug-loading system based on copper sulfide nanoparticles for combined photothermal therapy and chemotherapy in vivo
    Zhenwei Yuan, Sisi Qu, Yuanyuan He, Yue Xu, Li Liang, Xiaojing Zhou, Lijuan Gui, Yuqing Gu, and Haiyan Chen
    Biomaterials Science, 2018
    Website
  2. Methionine-decorated near infrared fluorescent probe for prolonged tumor imaging
    Chen Wei, Zhenwei Yuan, Jinrong Zheng, Habtamu Kassaye, Lijuan Gui, Fei Wang, Hao Wan, Yue Xu, Qing He, Murat Er, and  others
    Molecular Pharmaceutics, 2018
    Website