Yue Xu, PhD

Dr. Yue Xu is a UHN-PRiME postdoctoral fellow in Bowen Li’s lab at the Leslie Dan Faculty of Pharmacy, University of Toronto, whose research integrates artificial intelligence with molecular design and drug delivery to accelerate biomedical discovery. Trained in medicinal and lipid chemistry with a Ph.D. from China Pharmaceutical University, Dr. Xu brings a computational lens to experimental science, building AI-guided platforms to drive innovation in nanomedicine.
His current focus is on developing a high-throughput screening platform that leverages machine learning to optimize lipid nanoparticle (LNP) formulations for mRNA delivery. By combining modular lipid synthesis with real-time data acquisition and AI-driven modeling, his work enables rapid identification of delivery vectors with superior in vivo performance across intranasal, intratumoral, and systemic routes.He aims to lead interdisciplinary research programs in academia or industry that harness AI not as a tool, but as a scientific partner in the lab.
selected publications
- Proc. Natl. Acad. Sci. U.S.A.Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA deliveryProceedings of the National Academy of Sciences, 2025
- Nat. Commun.AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA deliveryNature communications, 2024
- Adv. Mater.Tumor-tailored ionizable lipid nanoparticles facilitate IL-12 circular RNA delivery for enhanced lung cancer immunotherapyAdvanced Materials, 2024
- Nat. Biomed. Eng.Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNANature Biomedical Engineering, 2023
- Proc. Natl. Acad. Sci. U.S.A.Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effectsProceedings of the National Academy of Sciences, 2023
- ACS Sens.β-Lactamase-responsive probe for efficient photodynamic therapy of drug-resistant bacterial infectionAcs Sensors, 2022
- J. Adv. Res.Development of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogsJournal of advanced research, 2021
- J. Med. Chem.Light-triggered fluorescence self-reporting nitric oxide release from coumarin analogues for accelerating wound healing and synergistic antimicrobial applicationsJournal of Medicinal Chemistry, 2021
- Anal. Chim. ActaA family of push-pull bio-probes for tracking lipid droplets in living cells with the detection of heterogeneity and polarityAnalytica Chimica Acta, 2020
- TalantaA visible and near-infrared, dual emission fluorescent probe based on thiol reactivity for selectively tracking mitochondrial glutathione in vitroTalanta, 2019