Yue Xu, PhD
I am an Instructor at Baylor College of Medicine since October 2025 and completed my UHN-PRiME postdoctoral fellowship in Bowen Li’s lab at the Leslie Dan Faculty of Pharmacy, University of Toronto. I was trained in medicinal chemistry, earning a Ph.D. from China Pharmaceutical University, and during my postdoctoral training I brought a computational perspective to experimental science, developing predictive models and analyses to guide synthesis and biological testing. My current work focuses on building a high-throughput screening platform using rational design to evaluate lipid nanoparticles (LNPs) for mRNA delivery.
selected publications
- PNASRational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA deliveryProceedings of the National Academy of Sciences, 2025
- Nat. Commun.AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA deliveryNature communications, 2024
- Adv. Mater.Tumor-tailored ionizable lipid nanoparticles facilitate IL-12 circular RNA delivery for enhanced lung cancer immunotherapyAdvanced Materials, 2024
- J. Mater. Chem. BRational design and combinatorial chemistry of ionizable lipids for RNA deliveryJournal of Materials Chemistry B, 2023
- Nat. Biomed. Eng.Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNANature Biomedical Engineering, 2023
- PNASCombinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effectsProceedings of the National Academy of Sciences, 2023
- ACS Sens.β-Lactamase-responsive probe for efficient photodynamic therapy of drug-resistant bacterial infectionAcs Sensors, 2022
- J. Adv. Res.Development of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogsJournal of advanced research, 2021
- J. Med. Chem.Light-triggered fluorescence self-reporting nitric oxide release from coumarin analogues for accelerating wound healing and synergistic antimicrobial applicationsJournal of Medicinal Chemistry, 2021
- Anal. Chim. ActaA family of push-pull bio-probes for tracking lipid droplets in living cells with the detection of heterogeneity and polarityAnalytica Chimica Acta, 2020
- TalantaA visible and near-infrared, dual emission fluorescent probe based on thiol reactivity for selectively tracking mitochondrial glutathione in vitroTalanta, 2019