Yue Xu, Ph.D.

prof_pic.jpg

I’m Yue Xu, a postdoctoral fellow at the Leslie Dan Faculty of Pharmacy, University of Toronto, affiliated with UHN-PRiME. My research lies at the intersection of medicinal chemistry, nanomedicine, and artificial intelligence (AI). Specifically, I focus on developing high-throughput screening platforms to optimize lipid nanoparticles (LNPs) for various biomedical applications.

During my academic journey, I earned a PhD in medicinal chemistry from China Pharmaceutical University. In my current role, I am particularly interested in leveraging AI to accelerate drug discovery processes. By integrating machine learning models with experimental workflows, I aim to enhance the reproducibility, explainability, and scalability of scientific research. My goal is to bridge the gap between computational predictions and experimental validation, enabling more efficient and precise therapeutic development.

selected publications

  1. PNAS
    Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery
    Yue Xu, Fanglin Gong, Alex Golubovic, Amy Strilchuk, Jingan Chen, Muye Zhou, Songtao Dong, Breanna Seto, and Bowen Li
    Proceedings of the National Academy of Sciences, 2025
  2. Nat Commun
    AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery
    Yue Xu, Shihao Ma, Haotian Cui, Jingan Chen, Shufen Xu, Fanglin Gong, Alex Golubovic, Muye Zhou, Kevin Chang Wang, Andrew Varley, and  others
    Nature communications, 2024
  3. bioRxiv
    LUMI-lab: a Foundation Model-Driven Autonomous Platform Enabling Discovery of New Ionizable Lipid Designs for mRNA Delivery
    Haotian Cui, Yue Xu, Kuan Pang, Gen Li, Fanglin Gong, Bo Wang, and Bowen Li
    bioRxiv, 2025
  4. J Mater Chem B
    Rational design and combinatorial chemistry of ionizable lipids for RNA delivery
    Yue Xu, Alex Golubovic, Shufen Xu, Anni Pan, and Bowen Li
    Journal of Materials Chemistry B, 2023
  5. J Adv Res
    Development of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogs
    Yue Xu, Hua Li, Lixue Fan, Yisha Chen, Li Li, Xiaojing Zhou, Ruixi Li, Yuru Cheng, Haiyan Chen, and Zhenwei Yuan
    Journal of advanced research, 2021
  6. J Med Chem
    Light-triggered fluorescence self-reporting nitric oxide release from coumarin analogues for accelerating wound healing and synergistic antimicrobial applications
    Yue Xu, Hua Li, Shufen Xu, Xian Liu, Jingjing Lin, Haiyan Chen, and Zhenwei Yuan
    Journal of Medicinal Chemistry, 2021
  7. Acs Sensors
    β-Lactamase-responsive probe for efficient photodynamic therapy of drug-resistant bacterial infection
    Yue Xu, Haiyan Chen, Shufen Xu, Ji Liu, Yang Chen, Lijuan Gui, Hua Li, Ruixi Li, Zhenwei Yuan, and Bowen Li
    Acs Sensors, 2022
  8. PNAS
    Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects
    Jingan Chen, Yue Xu, Muye Zhou, Shufen Xu, Andrew James Varley, Alex Golubovic, Rick Xing Ze Lu, Kevin Chang Wang, Mina Yeganeh, Daniel Vosoughi, and  others
    Proceedings of the National Academy of Sciences, 2023
  9. Adv Mater
    Tumor-tailored ionizable lipid nanoparticles facilitate IL-12 circular RNA delivery for enhanced lung cancer immunotherapy
    Shufen Xu, Yue Xu, Nicholas C Solek, Jingan Chen, Fanglin Gong, Andrew James Varley, Alex Golubovic, Anni Pan, Songtao Dong, Gang Zheng, and  others
    Advanced Materials, 2024
  10. Talanta
    A visible and near-infrared, dual emission fluorescent probe based on thiol reactivity for selectively tracking mitochondrial glutathione in vitro
    Yue Xu, Ruixi Li, Xiaojing Zhou, Weiqing Li, Umeorah Ernest, Hao Wan, Li Li, Haiyan Chen, and Zhenwei Yuan
    Talanta, 2019