prof_pic.jpg

Dr. Yue Xu is an Instructor at Baylor College of Medicine at Yong Li’s lab since October 2025 and completed his UHN-PRiME postdoctoral fellowship in Bowen Li’s lab at the Leslie Dan Faculty of Pharmacy, University of Toronto. He was trained in medicinal chemistry, earning a Ph.D. from China Pharmaceutical University, and during his postdoctoral training, he brought a computational perspective to experimental science, developing predictive models and analyses to guide synthesis and biological testing. His current work focuses on building a high-throughput screening platform using rational design to evaluate lipid nanoparticles (LNPs) for mRNA delivery.

News

Apr 2026 Yue Xu Was Selected for an Invited Oral Presentation at AACR 2026 — San Diego, CA, USA
Mar 2026 Yue Xu Was Invited to Speak at NIH NCI as a 2026 CAP-IT Early Career Investigator — Bethesda, MD, USA
Mar 2026 Yue Xu Will Join Children's Mercy and UMKC/KUMC as PI and Assistant Professor — Kansas City, MO/KS, USA
Feb 2026 Yue Xu Delivered a Grand Rounds Talk at BCM Epidemiology and Population Sciences — Houston, TX, USA
Oct 2025 Yue Xu Joined Baylor College of Medicine as an Instructor — Houston, TX, USA
Jan 2025 Yue Xu Received the SCBA Toronto Chapter 2025 Paper Award — Toronto, ON, Canada

Selected Publications (* Co-first author; # Corresponding author)

  1. Cell
    cui2026lumi.jpg
    LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery
    Yue Xu*, Haotian Cui*, Kuan Pang, Gen Li, Fanglin Gong, Songtao Dong, Bo Wang#, and Bowen Li#
    Cell, 2026
  2. Nat. Mater.
    gong2026nature_placeholder.jpg
    Biodegradable ionizable lipid nanoparticles for efficient mRNA delivery to the lung
    Fanglin Gong*, Yue Xu*, Jingan Chen, Siyang Zhang, Breanna Seto, Songtao Dong, Muye Zhou, Rick Lu, Gen Li, Yue Tang, Zihan Chen, Karen Antonio, Andrew Varley, Daniel Chen, Connor Hodges, Adrian Wong, Jiaxin Hu, Basil P Hubbard, John Engelhardt, Ziying Yan, and Bowen Li#
    Nature Materials, 2026
  3. Nat. Nanotechnol.
    dong2025nanotechnology_placeholder.jpg
    A modular mRNA platform for programmable induction of tumour-specific immunogenic cell death
    Songtao Dong*, Shannon Tsai*, Yue Xu, Fanglin Gong, Tiana Young, Nicholas Solek, Daniel Chen, Liam Healy*, Myroslav Savguira, Muye Zhou, Jingan Chen, Alex Golubovic, Rick Lu, Tian He, Haoyuan He, and Bowen Li#
    Nature Nanotechnology, 2025
  4. PNAS
    xu2025rational_placeholder.jpg
    Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery
    Yue Xu*, Fanglin Gong*, Alex Golubovic, Amy Strilchuk, Jingan Chen, Muye Zhou, Songtao Dong, Breanna Seto, and Bowen Li#
    Proceedings of the National Academy of Sciences, 2025
  5. Nat. Commun.
    xu2024agile.jpg
    AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery
    Yue Xu*, Shihao Ma*, Haotian Cui, Jingan Chen, Shufen Xu, Fanglin Gong, Alex Golubovic, Muye Zhou, Kevin Chang Wang, Andrew Varley, Rick Xing Ze Lu, Bo Wang#, and Bowen Li#
    Nature communications, 2024
  6. Adv. Mater.
    xu2024tumor_placeholder.jpg
    Tumor-tailored ionizable lipid nanoparticles facilitate IL-12 circular RNA delivery for enhanced lung cancer immunotherapy
    Shufen Xu*, Yue Xu*, Nicholas C Solek, Jingan Chen, Fanglin Gong, Andrew James Varley, Alex Golubovic, Anni Pan, Songtao Dong, Gang Zheng, and Bowen Li#
    Advanced Materials, 2024
  7. J. Mater. Chem. B
    xu2023rational.gif
    Rational design and combinatorial chemistry of ionizable lipids for RNA delivery
    Yue Xu*, Alex Golubovic*, Shufen Xu, Anni Pan, and Bowen Li#
    Journal of Materials Chemistry B, 2023
  8. Nat. Biomed. Eng.
    li2023enhancing.png
    Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA
    Bowen Li*, Allen Yujie Jiang*, Idris Raji, Caroline Atyeo, Theresa M Raimondo, Akiva GR Gordon, Luke H Rhym, Tahoura Samad, Corina MacIsaac, Jacob Witten, Haseeb Mughal, Taras M Chicz, Yue Xu, Ryan P McNamara, Sangeeta Bhatia, Galit Alter, Robert Langer, and Daniel G Anderson#
    Nature Biomedical Engineering, 2023
  9. PNAS
    chen2023combinatorial_placeholder.jpg
    Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects
    Jingan Chen*, Yue Xu*, Muye Zhou, Shufen Xu, Andrew James Varley, Alex Golubovic, Rick Xing Ze Lu, Kevin Chang Wang, Mina Yeganeh, Daniel Vosoughi, and Bowen Li#
    Proceedings of the National Academy of Sciences, 2023
  10. ACS Sens.
    xu2022beta_placeholder.jpg
    β-Lactamase-responsive probe for efficient photodynamic therapy of drug-resistant bacterial infection
    Yue Xu*, Haiyan Chen*, Shufen Xu, Ji Liu, Yang Chen, Lijuan Gui, Hua Li, Ruixi Li, Zhenwei Yuan#, and Bowen Li#
    Acs Sensors, 2022
  11. J. Adv. Res.
    xu2021development.jpg
    Development of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogs
    Yue Xu*, Hua Li*, Lixue Fan, Yisha Chen, Li Li, Xiaojing Zhou, Ruixi Li, Yuru Cheng, Haiyan Chen#, and Zhenwei Yuan#
    Journal of advanced research, 2021
  12. J. Med. Chem.
    xu2021light_placeholder.jpg
    Light-triggered fluorescence self-reporting nitric oxide release from coumarin analogues for accelerating wound healing and synergistic antimicrobial applications
    Yue Xu*, Hua Li*, Shufen Xu, Xian Liu, Jingjing Lin, Haiyan Chen#, and Zhenwei Yuan#
    Journal of Medicinal Chemistry, 2021
More forecasts: meteolongue.com