Yue Xu, PhD

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Dr. Yue Xu is a UHN-PRiME postdoctoral fellow in Bowen Li’s lab at the Leslie Dan Faculty of Pharmacy, University of Toronto, whose research integrates artificial intelligence with molecular design and drug delivery to accelerate biomedical discovery. Trained in medicinal and lipid chemistry with a Ph.D. from China Pharmaceutical University, Dr. Xu brings a computational lens to experimental science, building AI-guided platforms to drive innovation in nanomedicine.

His current focus is on developing a high-throughput screening platform that leverages machine learning to optimize lipid nanoparticle (LNP) formulations for mRNA delivery. By combining modular lipid synthesis with real-time data acquisition and AI-driven modeling, his work enables rapid identification of delivery vectors with superior in vivo performance across intranasal, intratumoral, and systemic routes.He aims to lead interdisciplinary research programs in academia or industry that harness AI not as a tool, but as a scientific partner in the lab.

selected publications

  1. Proc. Natl. Acad. Sci. U.S.A.
    Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery
    Yue Xu, Fanglin Gong, Alex Golubovic, Amy Strilchuk, Jingan Chen, Muye Zhou, Songtao Dong, Breanna Seto, and Bowen Li
    Proceedings of the National Academy of Sciences, 2025
  2. Nat. Commun.
    AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery
    Yue Xu, Shihao Ma, Haotian Cui, Jingan Chen, Shufen Xu, Fanglin Gong, Alex Golubovic, Muye Zhou, Kevin Chang Wang, Andrew Varley, and others
    Nature communications, 2024
  3. Adv. Mater.
    Tumor-tailored ionizable lipid nanoparticles facilitate IL-12 circular RNA delivery for enhanced lung cancer immunotherapy
    Shufen Xu, Yue Xu, Nicholas C Solek, Jingan Chen, Fanglin Gong, Andrew James Varley, Alex Golubovic, Anni Pan, Songtao Dong, Gang Zheng, and others
    Advanced Materials, 2024
  4. Nat. Biomed. Eng.
    Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA
    Bowen Li, Allen Yujie Jiang, Idris Raji, Caroline Atyeo, Theresa M Raimondo, Akiva GR Gordon, Luke H Rhym, Tahoura Samad, Corina MacIsaac, Jacob Witten, and others
    Nature Biomedical Engineering, 2023
  5. Proc. Natl. Acad. Sci. U.S.A.
    Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects
    Jingan Chen, Yue Xu, Muye Zhou, Shufen Xu, Andrew James Varley, Alex Golubovic, Rick Xing Ze Lu, Kevin Chang Wang, Mina Yeganeh, Daniel Vosoughi, and others
    Proceedings of the National Academy of Sciences, 2023
  6. ACS Sens.
    β-Lactamase-responsive probe for efficient photodynamic therapy of drug-resistant bacterial infection
    Yue Xu, Haiyan Chen, Shufen Xu, Ji Liu, Yang Chen, Lijuan Gui, Hua Li, Ruixi Li, Zhenwei Yuan, and Bowen Li
    Acs Sensors, 2022
  7. J. Adv. Res.
    Development of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogs
    Yue Xu, Hua Li, Lixue Fan, Yisha Chen, Li Li, Xiaojing Zhou, Ruixi Li, Yuru Cheng, Haiyan Chen, and Zhenwei Yuan
    Journal of advanced research, 2021
  8. J. Med. Chem.
    Light-triggered fluorescence self-reporting nitric oxide release from coumarin analogues for accelerating wound healing and synergistic antimicrobial applications
    Yue Xu, Hua Li, Shufen Xu, Xian Liu, Jingjing Lin, Haiyan Chen, and Zhenwei Yuan
    Journal of Medicinal Chemistry, 2021
  9. Anal. Chim. Acta
    A family of push-pull bio-probes for tracking lipid droplets in living cells with the detection of heterogeneity and polarity
    Li Li, Yue Xu, Yisha Chen, Jinrong Zheng, Juanjuan Zhang, Ruixi Li, Hao Wan, Jun Yin, Zhenwei Yuan, and Haiyan Chen
    Analytica Chimica Acta, 2020
  10. Talanta
    A visible and near-infrared, dual emission fluorescent probe based on thiol reactivity for selectively tracking mitochondrial glutathione in vitro
    Yue Xu, Ruixi Li, Xiaojing Zhou, Weiqing Li, Umeorah Ernest, Hao Wan, Li Li, Haiyan Chen, and Zhenwei Yuan
    Talanta, 2019