Dr. Yue Xu is an Instructor at Baylor College of Medicine at Yong Li’s lab since October 2025 and completed his UHN-PRiME postdoctoral fellowship in Bowen Li’s lab at the Leslie Dan Faculty of Pharmacy, University of Toronto. He was trained in medicinal chemistry, earning a Ph.D. from China Pharmaceutical University, and during his postdoctoral training, he brought a computational perspective to experimental science, developing predictive models and analyses to guide synthesis and biological testing. His current work focuses on building a high-throughput screening platform using rational design to evaluate lipid nanoparticles (LNPs) for mRNA delivery.
News
| Apr 2026 | Yue Xu Was Selected for an Invited Oral Presentation at AACR 2026 | — San Diego, CA, USA |
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| Mar 2026 | Yue Xu Was Invited to Speak at NIH NCI as a 2026 CAP-IT Early Career Investigator | — Bethesda, MD, USA |
| Mar 2026 | Yue Xu Will Join Children's Mercy and UMKC/KUMC as PI and Assistant Professor | — Kansas City, MO/KS, USA |
| Feb 2026 | Yue Xu Delivered a Grand Rounds Talk at BCM Epidemiology and Population Sciences | — Houston, TX, USA |
| Oct 2025 | Yue Xu Joined Baylor College of Medicine as an Instructor | — Houston, TX, USA |
| Jan 2025 | Yue Xu Received the SCBA Toronto Chapter 2025 Paper Award | — Toronto, ON, Canada |
Selected Publications (* Co-first author; # Corresponding author)
- Nat. Mater.
Biodegradable ionizable lipid nanoparticles for efficient mRNA delivery to the lungNature Materials, 2026 - Nat. Nanotechnol.
A modular mRNA platform for programmable induction of tumour-specific immunogenic cell deathNature Nanotechnology, 2025 - PNAS
Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA deliveryProceedings of the National Academy of Sciences, 2025 - Nat. Commun.
AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA deliveryNature communications, 2024 - Adv. Mater.
Tumor-tailored ionizable lipid nanoparticles facilitate IL-12 circular RNA delivery for enhanced lung cancer immunotherapyAdvanced Materials, 2024 - J. Mater. Chem. B
Rational design and combinatorial chemistry of ionizable lipids for RNA deliveryJournal of Materials Chemistry B, 2023 - Nat. Biomed. Eng.
Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNANature Biomedical Engineering, 2023 - PNAS
Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effectsProceedings of the National Academy of Sciences, 2023 - ACS Sens.
β-Lactamase-responsive probe for efficient photodynamic therapy of drug-resistant bacterial infectionAcs Sensors, 2022 - J. Adv. Res.
Development of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogsJournal of advanced research, 2021 - J. Med. Chem.
Light-triggered fluorescence self-reporting nitric oxide release from coumarin analogues for accelerating wound healing and synergistic antimicrobial applicationsJournal of Medicinal Chemistry, 2021
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