Yue Xu, Ph.D.

I’m Yue Xu, a postdoctoral fellow at the Leslie Dan Faculty of Pharmacy, University of Toronto, affiliated with UHN-PRiME. My research lies at the intersection of medicinal chemistry, nanomedicine, and artificial intelligence (AI). Specifically, I focus on developing high-throughput screening platforms to optimize lipid nanoparticles (LNPs) for various biomedical applications.
During my academic journey, I earned a PhD in medicinal chemistry from China Pharmaceutical University. In my current role, I am particularly interested in leveraging AI to accelerate drug discovery processes. By integrating machine learning models with experimental workflows, I aim to enhance the reproducibility, explainability, and scalability of scientific research. My goal is to bridge the gap between computational predictions and experimental validation, enabling more efficient and precise therapeutic development.
selected publications
- PNASRational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA deliveryProceedings of the National Academy of Sciences, 2025
- Nat CommunAGILE platform: a deep learning powered approach to accelerate LNP development for mRNA deliveryNature communications, 2024
- bioRxivLUMI-lab: a Foundation Model-Driven Autonomous Platform Enabling Discovery of New Ionizable Lipid Designs for mRNA DeliverybioRxiv, 2025
- J Mater Chem BRational design and combinatorial chemistry of ionizable lipids for RNA deliveryJournal of Materials Chemistry B, 2023
- J Adv ResDevelopment of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogsJournal of advanced research, 2021
- J Med ChemLight-triggered fluorescence self-reporting nitric oxide release from coumarin analogues for accelerating wound healing and synergistic antimicrobial applicationsJournal of Medicinal Chemistry, 2021
- Acs Sensorsβ-Lactamase-responsive probe for efficient photodynamic therapy of drug-resistant bacterial infectionAcs Sensors, 2022
- PNASCombinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effectsProceedings of the National Academy of Sciences, 2023
- Adv MaterTumor-tailored ionizable lipid nanoparticles facilitate IL-12 circular RNA delivery for enhanced lung cancer immunotherapyAdvanced Materials, 2024
- TalantaA visible and near-infrared, dual emission fluorescent probe based on thiol reactivity for selectively tracking mitochondrial glutathione in vitroTalanta, 2019